Deformation and slip behavior along subduction zone interfaces are profoundly influenced by their thermal, mechanical, and hydraulic conditions. In particular, subducting plate roughness—such as seamounts, fracture zones, and variations in sediment thickness—can generate frictional heat, concentrate stress, and create asperities, all of which critically affect the style and magnitude of seismic rupture, including the generation of megathrust earthquakes, slow slip events, and tsunami earthquakes. This project aims to unravel how plate interface roughness controls fault slip behavior and seismogenesis. We employ both analogue and numerical modeling to investigate seismic behavior under varying roughness conditions, using the Chilean subduction zone as a case study. These models are designed to advance our understanding of the structural controls on earthquake behavior and the mechanisms of megathrust seismogenesis, ultimately contributing to improved seismic hazard assessments.